Prescription & OTC Drugs – Douglas A. GREENE, Rajiv R. Ratan, Thomas I. Bradshaw, Burke Neurological Institute, Neuronasal Inc
Abstract for “Methods for treating brain disorders”
The present disclosure describes intranasal administration of N-acetylcysteine, (NAC), via nose-to brain administration. An analytical technique such as magnetic resonance spectroscopy can be used to monitor the effect of NAC nose-to brain administration. Intranasal nose to brain NAC may be used in some instances to treat a condition such as a brain injury.
Background for “Methods for treating brain disorders”
“INCORPORATION BY RESEARCH”
“Compounds” of the Disclosure
“Purity Of Compounds of The Disclosure”
“Intranasal Nose-to-Brain Delivery”
“Therapeutic Methods”
“Pharmaceutical Compositions”
“Modes of Administration.”
“Dosing”
“Combination Therapy”
“Therapeutic Effects”
“Subjects”
“Clinical Assessment Tools.”
“EXAMPLES”
“Example 1 – Phase I Study on Brain Bioavailability & Safety of Intranasal NAAC”
“Statistical Methods”
“Example 2 – Investigational Product, Dosage and Mode of Administration”
“Example 3 – Study Evaluations and Measurements
“Example 4 – Single Ascending Dose Stud”
“Example 5 – Administration of Nose to Brain NAC”
“Example 6 – Administration of Nose to Brain GSH”
“Example 7 – Measuring Nose to Brain NAC or GSH Delivery Using Magnetic Resonance Spectroscopy
“Example 8 – Administration of Intranasal Nose to Brain NAC to a Subject With a Military-Related Traumatic Head Injury”
“Embodiments”
Summary for “Methods for treating brain disorders”
“INCORPORATION BY RESEARCH”
“Compounds” of the Disclosure
“Purity Of Compounds of The Disclosure”
“Intranasal Nose-to-Brain Delivery”
“Therapeutic Methods”
“Pharmaceutical Compositions”
“Modes of Administration.”
“Dosing”
“Combination Therapy”
“Therapeutic Effects”
“Subjects”
“Clinical Assessment Tools.”
“EXAMPLES”
“Example 1 – Phase I Study on Brain Bioavailability & Safety of Intranasal NAAC”
“Statistical Methods”
“Example 2 – Investigational Product, Dosage and Mode of Administration”
“Example 3 – Study Evaluations and Measurements
“Example 4 – Single Ascending Dose Stud”
“Example 5 – Administration of Nose to Brain NAC”
“Example 6 – Administration of Nose to Brain GSH”
“Example 7 – Measuring Nose to Brain NAC or GSH Delivery Using Magnetic Resonance Spectroscopy
“Example 8 – Administration of Intranasal Nose to Brain NAC to a Subject With a Military-Related Traumatic Head Injury”
“Embodiments”
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