Animal Health – Samuel Strober, Alexander Filatenkov, Leland Stanford Junior University
Abstract for “Tumor vaccination combined with hematopoietic cells transplantation for cancer treatment”
“The present invention offers a method of treating cancer that includes tumor cell vaccination combined with hematopoietic or immune cell transplantation. The method may include autologous tumor cells vaccination before autologous hematopoietic or immune cell transplantation. The present invention also provides a method for purifying tumor cells from subjects in preparation to vaccination.
Background for “Tumor vaccination combined with hematopoietic cells transplantation for cancer treatment”
“INCORPORATION BY RESEARCH”
“Cancer Immunotherapy”
“Tumor Cell Purification to Vaccination”
“Tumor Vaccination & Hematopoietic Cell Transplantation, (HCT), as Cancer Therapy”
“Methods for Treatment: Anti-Cancer Therapy.”
Antineoplastic Chemotherapeutic agents
“Alkylating Agents”
“Antimetabolites”
“Natural Antineoplastic Agents.”
“Hormonal Antineoplastic Agents.”
“Angiogenesis Inhibitors”
“Differentiating Reagents”
“Antibodies/Immunotherapeutic Agents”
“Gene Therapy Agents”
“Nanotherapy”
“RNA Therapy”
“Small Molecule Enzymatic Ihibitors”
“Biological Response Modifiers”
“Anti-Metastatic Agents”
“Chemopreventative Agents”
“Side-Effect Limiting Agents”
“EXAMPLES”
“Example 1”
“Hematopoietic Cell Transplantation from Vaccinated BALB/c Donor Mouse Cures Established CT26 Colon Tumors.”
“Example 2”
“Vaccination and HCT induce long-term anti-tumor immunity”
“Example 3”
“Tumor Eradication requires Lethal Irradiation Of Hosts as Well As Transfer of CD4+ & CD8+ T cells from Vaccinated Donors.”
“Example 4”
“Analysis Of Donor T Cells In Host Tumors And Spleens After Transplantation: Radiation Promotes Tumor Cell Accumulation”
“Example 5”
“HCT Alters The Balance Between Regulatory And Effector Cells at the Tumor Site.”
“Example 6”
“Tumor Vaccination is Effective When Combined With HCT and Vaccine InducedAnti-Tumor Immunity Is Not Prevented By the Presence Of Growing Tumors”
“Example 7”
“Autologous HCT enhances tumor immunity after vaccination”
“Example 8”
“Clinical Study to Evaluate the Safety and Feasibility Of Autologous Tumor Cell – TLR9 Agonist Vaccination prior to Autologous Hematopoietic And Immune Cell Rescue In Metastatic Colorectal Cancer.”
“Objectives”
“Correlative Studies Background”
“Participant Selection & Enrollment Procedures”
“Exclusion Criteria”
“Treatment Plan”
“Adverse Events and Reporting Methods”
“Definitions for Adverse Events”
“Correlative Studies”
“Measurement Of Effect”
“Other Response Parameters?
“Statistical Considerations”
“Endpoints”
“Secondary Endpoints”
“Plan of Analysis”
“REFERENCES”
Summary for “Tumor vaccination combined with hematopoietic cells transplantation for cancer treatment”
“INCORPORATION BY RESEARCH”
“Cancer Immunotherapy”
“Tumor Cell Purification to Vaccination”
“Tumor Vaccination & Hematopoietic Cell Transplantation, (HCT), as Cancer Therapy”
“Methods for Treatment: Anti-Cancer Therapy.”
Antineoplastic Chemotherapeutic agents
“Alkylating Agents”
“Antimetabolites”
“Natural Antineoplastic Agents.”
“Hormonal Antineoplastic Agents.”
“Angiogenesis Inhibitors”
“Differentiating Reagents”
“Antibodies/Immunotherapeutic Agents”
“Gene Therapy Agents”
“Nanotherapy”
“RNA Therapy”
“Small Molecule Enzymatic Ihibitors”
“Biological Response Modifiers”
“Anti-Metastatic Agents”
“Chemopreventative Agents”
“Side-Effect Limiting Agents”
“EXAMPLES”
“Example 1”
“Hematopoietic Cell Transplantation from Vaccinated BALB/c Donor Mouse Cures Established CT26 Colon Tumors.”
“Example 2”
“Vaccination and HCT induce long-term anti-tumor immunity”
“Example 3”
“Tumor Eradication requires Lethal Irradiation Of Hosts as Well As Transfer of CD4+ & CD8+ T cells from Vaccinated Donors.”
“Example 4”
“Analysis Of Donor T Cells In Host Tumors And Spleens After Transplantation: Radiation Promotes Tumor Cell Accumulation”
“Example 5”
“HCT Alters The Balance Between Regulatory And Effector Cells at the Tumor Site.”
“Example 6”
“Tumor Vaccination is Effective When Combined With HCT and Vaccine InducedAnti-Tumor Immunity Is Not Prevented By the Presence Of Growing Tumors”
“Example 7”
“Autologous HCT enhances tumor immunity after vaccination”
“Example 8”
“Clinical Study to Evaluate the Safety and Feasibility Of Autologous Tumor Cell – TLR9 Agonist Vaccination prior to Autologous Hematopoietic And Immune Cell Rescue In Metastatic Colorectal Cancer.”
“Objectives”
“Correlative Studies Background”
“Participant Selection & Enrollment Procedures”
“Exclusion Criteria”
“Treatment Plan”
“Adverse Events and Reporting Methods”
“Definitions for Adverse Events”
“Correlative Studies”
“Measurement Of Effect”
“Other Response Parameters?
“Statistical Considerations”
“Endpoints”
“Secondary Endpoints”
“Plan of Analysis”
“REFERENCES”
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