Animal Health – Hazel H. Szeto, Scott Kline Powers, Cornell University, University of Florida Research Foundation Inc
Abstract for “Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy”
“The present disclosure reveals methods and compositions that can be used to prevent or treat MV-induced or use-induced skeletal muscle infirmities. These methods also include the administration to the subject of an effective amount an aromatic-cationic protein.
Background for “Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy”
“I. Aromatic-Cationic Peptides”
“Lys-D-Arg-Tyr-NH2”
“Phe-D-Arg-His”
“D-Tyr-Trp-Lys-NH2”
“Trp-D-Lys-Tyr-Arg-NH2”
“Tyr-His-D-Gly-Met”
“Phe-Arg-D-His-Asp”
“Tyr-D-Arg-Phe-Lys-Glu-NH2”
“Met-Tyr-D-Lys-Phe-Arg”
“D-His-Glu-Lys-Tyr-D-Phe-Arg”
“Lys-D-Gln-Tyr-Arg-D-Phe-Trp-NH2”
“Phe-D-Arg-Lys-Trp-Tyr-D-Arg-His”
“Gly-D-Phe-Lys-Tyr-His-D-Arg-Tyr-NH2”
“Val-D-Lys-His-Tyr-D-Phe-Ser-Tyr-Arg-NH2”
“Trp-Lys-Phe-D-Asp-Arg-Tyr-D-His-Lys”
“Lys-Trp-D-Tyr-Arg-Asn-Phe-Tyr-D-His-NH2”
“Thr-Gly-Tyr-Arg-D-His-Phe-Trp-D-His-Lys”
“Asp-D-Trp-Lys-Tyr-D-His-Phe-Arg-D-Gly-Lys-NH2”
“D-His-Lys-Tyr-D-Phe-Glu-D-Asp-D-His-D-Lys-Arg-Trp-NH2”
“Ala-D-Phe-D-Arg-Tyr-Lys-D-Trp-His-D-Tyr-Gly-Phe”
“Tyr-D-His-Phe-D-Arg-Asp-Lys-D-Arg-His-Trp-D-His-Phe”
“Phe-Phe-D-Tyr-Arg-Glu-Asp-D-Lys-Arg-D-Arg-His-Phe-NH2”
“Phe-Try-Lys-D-Arg-Trp-His-D-Lys-D-Lys-Glu-Arg-D-Tyr-Thr”
“Tyr-Asp-D-Lys-Tyr-Phe-D-Lys-D-Arg-Phe-Pro-D-Tyr-His-Lys”
“Glu-Arg-D-Lys-Tyr-D-Val-Phe-D-His-Trp-Arg-D-Gly-Tyr-Arg-D-Met-NH2”
“Arg-D-Leu-D-Tyr-Phe-Lys-Glu-D-Lys-Arg-D-Trp-Lys-D-Phe-Tyr-D-Arg-Gly”
“D-Glu-Asp-Lys-D-Arg-D-His-Phe-Phe-D-Val-Tyr-Arg-Tyr-D-Tyr-Arg-His-Phe-NH2”
“Asp-Arg-D-Phe-Cys-Phe-D-Arg-D-Lys-Tyr-Arg-D-Tyr-Trp-D-His-Tyr-D-Phe-Lys-Phe”
“His-Tyr-D-Arg-Trp-Lys-Phe-D-Asp-Ala-Arg-Cys-D-Tyr-His-Phe-D-Lys-Tyr-His-Ser-NH2”
“Gly-Ala-Lys-Phe-D-Lys-Glu-Arg-Tyr-His-D-Arg-D-Arg-Asp-Tyr-Trp-D-His-Trp-His-D-Lys-Asp”
“Thr-Tyr-Arg-D-Lys-Trp-Tyr-Glu-Asp-D-Lys-D-Arg-His-Phe-D-Tyr-Gly-Val-Ile-D-His-Arg-Tyr-Lys-NH2”
“II. “II.
“III. Modes of administration and dosages
“EXAMPLES”
“I. “I.
“II. “II.
“Animals”
“Experimental Design”
“Experimental Protocol”
“Biochemical Measures”
“Histological Measures”
“Statistical Analysis”
Summary for “Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy”
“I. Aromatic-Cationic Peptides”
“Lys-D-Arg-Tyr-NH2”
“Phe-D-Arg-His”
“D-Tyr-Trp-Lys-NH2”
“Trp-D-Lys-Tyr-Arg-NH2”
“Tyr-His-D-Gly-Met”
“Phe-Arg-D-His-Asp”
“Tyr-D-Arg-Phe-Lys-Glu-NH2”
“Met-Tyr-D-Lys-Phe-Arg”
“D-His-Glu-Lys-Tyr-D-Phe-Arg”
“Lys-D-Gln-Tyr-Arg-D-Phe-Trp-NH2”
“Phe-D-Arg-Lys-Trp-Tyr-D-Arg-His”
“Gly-D-Phe-Lys-Tyr-His-D-Arg-Tyr-NH2”
“Val-D-Lys-His-Tyr-D-Phe-Ser-Tyr-Arg-NH2”
“Trp-Lys-Phe-D-Asp-Arg-Tyr-D-His-Lys”
“Lys-Trp-D-Tyr-Arg-Asn-Phe-Tyr-D-His-NH2”
“Thr-Gly-Tyr-Arg-D-His-Phe-Trp-D-His-Lys”
“Asp-D-Trp-Lys-Tyr-D-His-Phe-Arg-D-Gly-Lys-NH2”
“D-His-Lys-Tyr-D-Phe-Glu-D-Asp-D-His-D-Lys-Arg-Trp-NH2”
“Ala-D-Phe-D-Arg-Tyr-Lys-D-Trp-His-D-Tyr-Gly-Phe”
“Tyr-D-His-Phe-D-Arg-Asp-Lys-D-Arg-His-Trp-D-His-Phe”
“Phe-Phe-D-Tyr-Arg-Glu-Asp-D-Lys-Arg-D-Arg-His-Phe-NH2”
“Phe-Try-Lys-D-Arg-Trp-His-D-Lys-D-Lys-Glu-Arg-D-Tyr-Thr”
“Tyr-Asp-D-Lys-Tyr-Phe-D-Lys-D-Arg-Phe-Pro-D-Tyr-His-Lys”
“Glu-Arg-D-Lys-Tyr-D-Val-Phe-D-His-Trp-Arg-D-Gly-Tyr-Arg-D-Met-NH2”
“Arg-D-Leu-D-Tyr-Phe-Lys-Glu-D-Lys-Arg-D-Trp-Lys-D-Phe-Tyr-D-Arg-Gly”
“D-Glu-Asp-Lys-D-Arg-D-His-Phe-Phe-D-Val-Tyr-Arg-Tyr-D-Tyr-Arg-His-Phe-NH2”
“Asp-Arg-D-Phe-Cys-Phe-D-Arg-D-Lys-Tyr-Arg-D-Tyr-Trp-D-His-Tyr-D-Phe-Lys-Phe”
“His-Tyr-D-Arg-Trp-Lys-Phe-D-Asp-Ala-Arg-Cys-D-Tyr-His-Phe-D-Lys-Tyr-His-Ser-NH2”
“Gly-Ala-Lys-Phe-D-Lys-Glu-Arg-Tyr-His-D-Arg-D-Arg-Asp-Tyr-Trp-D-His-Trp-His-D-Lys-Asp”
“Thr-Tyr-Arg-D-Lys-Trp-Tyr-Glu-Asp-D-Lys-D-Arg-His-Phe-D-Tyr-Gly-Val-Ile-D-His-Arg-Tyr-Lys-NH2”
“II. “II.
“III. Modes of administration and dosages
“EXAMPLES”
“I. “I.
“II. “II.
“Animals”
“Experimental Design”
“Experimental Protocol”
“Biochemical Measures”
“Histological Measures”
“Statistical Analysis”
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