Invented by Armand Bytton, Plant Synergy Inc
The Plant Synergy Inc invention works as followsA method for extracting C. yanhusuo plants, comprising of the steps of drying and harvesting the plant, extracting alkaloids in a solvent from the plant and filtering the solvent?” C. The method involves drying spent plant material, removing the solvent from it and the alkaloids extracted from it. It then involves purifying the alkaloids and separating them from the solvent. The method also produces vaporizing fluids, medicinal compositions and kief compositions as well as rolling papers and tobacco filters. “A C. yanhusuo with a total content of alkaloids of approximately 3%. Of this, 97% is bulbocapnine, and the remaining 3% is tetrahydropalmatine.
Background for High yield extraction method and products from Corydalis plants
The historically therapeutic plant Corydalis is native to the high altitude grasslands in China. At least 470 species are in the Corydalis family, and Corydalis Yanhusuo is an important medicinal plant for traditional Chinese medicine. The tuber is processed by a combination drying, grinding or fermenting, to produce a product that is used as an analgesic in traditional Chinese medicine.
The secondary metabolites in plant material or crude plant extracts that are traditionally consumed ingestion may have multiple effects on the body at once. These complex mixtures phytochemicals can have multiple, synergistic and “minor” effects on the body. Metabolites can have a balancing effect on targets, which could, for example reduce side effects compared to synthetic pharmaceuticals. The overall effect could be more desirable than a single compound.
The cannabis plant produces hundreds of compounds, each with its own therapeutic potential. They can also produce synergic reactions when combined. This enhanced effect is called the “entourage” effect. The entourage effect, which is caused by the undescribed but supportive molecules found in whole plant extracts, can often potentiate target molecules and produce a better result. One study compared the anti-tumor effects of the botanical drug preparations (whole plant extraction) with pure tetrahydrocannabinol against breast cancer.
The scientific community is not able to access the extraction processes of alkaloids that influence the entourage effects.
The alkaloids contained in Corydalis yanhusuo are believed to possess significant bioactivity and at least include bulbocapnine, tetrahydropalmatine (THP), in addition to protopine, ?-allocryptopine, tetrahydrocolumbamine, coptisine, palmatine, berberine, dhydrocorydaline, tetrahydroberberine, corydaline, and tetrahydrocoptisine.
Plant hybridization can occur both naturally and by cultivation. Hybridized medicinal and non-medicinal plant species provide many benefits. These include phytochemical and phytonutrient enhanced properties, and increased yields for certain alkaloids which have not yet been further researched or discovered. These plants are desirable for embodiments of present extraction methods because they can produce unique compositions.
Two receptors of the endocannabinoid systems, CB1 & CB2, have been identified to date, and consensus is that more could still be found. CB1 receptors and CB2 are both G protein coupled receptors. Endocannabinoids are retrograde messengers that activate presynaptic receptors of CB1 on brain neurons. This stimulation leads to regulation of ion channels, inhibition of adenylate-cyclase activities and activation the mitogen activated protein kinase (MAPK) cascade.
CB1 receptors have been found in high concentrations in the brain of mammals. They are also present in peripheral tissues and cells, such as the testis, the eye, the urinary bladder and the ileum, but in lower amounts than the brain. CB1 receptors can be found in areas of the brain that are involved with anxiety and emotion perception. CB1 receptors were found in rats’ amygdale with 5-HT transporters, suggesting they may be a target to treat disorders related mood, anxiety, and cognition.
Corydalis (e.g. Corydalis species (e.g. China has traditionally used the mood-enhancing and stimulating properties of Corydalis extract. C. yanhusuo preparations have also shown to reduce pain. These effects were confirmed by the serotonin uptake inhibition activity of unfermented alkaloid.
The current extraction methods to improve these properties and their effects on the biochemical reactions in the endocannabinoid systems remain undeveloped.
The method includes harvesting and drying of the C.yanhusuo plants; extracting alkaloids in a solvent from the C.yanhusuo plants; filtering of the solvent/C. The C. mixture is then filtered to remove the alkaloids and solvent from a C. spent C.
The method of extraction also provides a vaporizing fluid containing a mixture consisting of the purified C. yanhusuo plant material and the dried spent C.yanhusuo plants. A vaporizing fluid is also provided where the extraction method includes a step for solubilizing the plant matter in a second liquid.
Further, provided is a composition containing a mixture consisting of purified alkaloids with dried C. yanhusuo spent plant matter that was produced using the extraction method.
Also, a kief-composition is provided that contains a mixture consisting of the purified C. yanhusuo plants and the dried plant material produced by the extraction method.
Even more provided are papers for burning, such as in smoking, that have been impregnated with or coated with the mixture of purified alkaloids, and dried C. yanhusuo spent plant matter, produced according to method of extraction.
A C.yanhusuo with a total content of alkaloids of 3%. 97% of this total content is bulbocapnine, and tetrahydropalmatine
Also, provided are filters for example, for smoking or vapourization equipment that contain, impregnate or coat, a mixture consisting of purified alkaloids, and dried spent C.yanhusuo plants matter produced according the method of extract.
The following detailed description, taken together with the accompanying illustrations, will reveal many other features and benefits of the invention. Before describing embodiments of this invention in depth, it’s important to understand that the invention does not limit its application to details of construction or to the arrangement of components shown in the following description. The invention can be embodied in other ways and practiced or carried out differently. It is important to note that the terminology and phraseology used herein are intended for description only and not as a limitation.
Before describing the invention in detail, it might be helpful to define certain terms and phrases that are used throughout the patent document. The word “comprise” is used throughout this specification unless it is required by the context. The word ‘comprises’ or a variation such as ‘comprises’ The term ‘includes? The term ‘includes’ or a variation thereof, or the term “having” The term ‘includes’ The term ‘or variations thereof’ will be understood as implying the inclusion of an element, integer, or group of integers or elements that is stated but not the exclusion or any other element, integer, or group. A person who is skilled in reading claims should also understand that “a” and “an? The terms?a? Each of these words generally means ‘at least one.’ It does not exclude multiples unless context dictates otherwise. The term “or” is also used. The term ‘or’ denotes “at least one item, but does not exclude a plurality of items.” “But does not exclude multiple items from the list.
The invention described in this document is capable of other modifications and variations than those described. The invention is understood to include all variations and modifications that fall within the spirit and scope of its design.
The following are methods for high yield extraction and the products of Corydalis Yanhusuo plants, both for commercial and medicinal use.Click here to view the patent on Google Patents.